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Sample Preparation:  
Trypsin Digestion of Proteins in Solution



Sample clean-up and trypsin digestion in solution
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Sample Preparation:
Trypsin Digestion of In-Gel Proteins


Following are some general protocols for the enzymatic digestion of proteins separated by 1-D or 2-D electrophoresis.  Please note that samples vary dramatically, and conditions (materials, methods & reagents) must be optimized for individual sample types.

Silver Stained Gels (with destaining)  
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Silver Stained Gels (without destaining)  
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Coomassie Stained Gels
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Reagents
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Clean-up of digested proteins by Zip Tip
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Suggestions for obtaining intact protein from gels (caution: low yield)      HTML