MASS SPECTROMETRY FACILITY UA Dept of Chemistry
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Current Research
Implementation of CID and SID on a Sector/Time-of-Flight Hybrid Mass Spectrometer We have extended our JEOL HX110A sector instrument with a TOF analyzer in a linear arrangement. The main advantage of our design is that both high energy CID and low energy SID MS/MS experiments can be performed without changing the hardware (i.e., venting the instrument). For further details and other references, see: Nikolaev, E. N., Somogyi, A.; Gu, C.; Wysocki, V. H.; Martin, C. D.; Cody, R. B. Anal. Chem., submitted. Fragmentation Mechanisms of Protonated Peptides In collaboration with the
Wysocki group
, we are involved in research projects related to peptide fragmentation.
The high energy CID (JEOL HX110A-TOF and low energy CID (Finnigan LCQ) instruments
are used to provide additional experimental data to those obtained by SID.
Ion Neutralization in Low-Energy Ion-Surface Collisions The neutralization of projectile ions in
low-energy ion-surface collisions is a "non-desired" but unavoidable process
that may lead to a significant loss of ion signal in SID experiments. Quantum
chemical methods provide further insight into the neutralization process
the product of which are difficult to detect experimentally.
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