CURRICULUM VITAE Michael F. Brown
Department of Chemistry
University of Arizona
Tucson, Arizona 85721
U.S.A. Telephone: (602) 621-2163
FAX: (602) 621-8407
E-MAIL: MFBROWN@U.ARIZONA.EDU
EDUCATION
1975 Ph.D., University of California, Santa Cruz
1970 A.B., University of California, Santa Cruz
ACADEMIC APPOINTMENTS
Present Positions:
1987-Professor of Chemistry (primary appointment), University of Arizona
1987-Professor of Biochemistry, University of Arizona
1987-Visiting Professor of Physical Chemistry, University of Lund,
Sweden
1993-Professor, Committee on Neuroscience, University of Arizona
Previous Positions:
1985-87 Associate Professor of Chemistry (with Tenure), University
of Virginia
1980-85 Assistant Professor of Chemistry, University of Virginia
1979-80 Postdoctoral Fellow, Department of Chemistry, University of
California, Berkeley
1976-78 Postdoctoral Fellow, Biocenter, University of Basel, Switzerland
TEACHING EXPERIENCE AND COURSES TAUGHT
Undergraduate Level:
Fundamentals of Chemistry, CHEM 103b (UA)
Biological Chemistry Seminar, CHEM 252 (UVa)
Biological Chemistry Seminar, CHEM 296a (UA)
Physical Chemistry, CHEM 341 (UVa)
Biological Chemistry, CHEM 442 (UVa)
Biological Chemistry Laboratory, CHEM 452 (UVa)
Physical Chemistry, CHEM 480a (UA)
Physical Chemistry, CHEM 480b (UA)
Biophysical Chemistry, CHEM 481 (UA)
Graduate Level:
Intermediate Physical Chemistry, CHEM 503 (UA)
Practical NMR Spectroscopy, CHEM 584 (UA)
Magnetic Resonance Spectroscopy, CHEM 684 (UA)
HONORS AND PRIZES
1990 Röntgen Professorship of Physics, Germany
1985-90 U.S. National Institutes of Health Research Career Development
Award
1983-85 Alfred P. Sloan Foundation Research Fellowship
OTHER HONORS
1979-80U.S. National Institutes of Health Postdoctoral Fellowship,
University of California, Berkeley
1976-78U.S. National Institutes of Health Postdoctoral Fellowship,
University of Basel, Switzerland
1970-72University of California Graduate Fellowship
1970 California State Graduate Fellowship
1969 President's Scholarship, University of California
1968-70 California State Scholarship
1968-69 University of California Scholarship
PROFESSIONAL SOCIETIES
Biophysical Society
American Association for the Advancement of Science
RESEARCH INTERESTS
Nuclear magnetic resonance (NMR) spectroscopy; magnetic resonance
imaging (MRI);liquid crystals and surfactants; role of surface chemistry
in art restoration; biophysical chemistry of membranes; lipid-protein interactions;
molecular basis of visual excitation; structure and dynamics of proteins.
PATENTS - TECHNOLOGY TRANSFER
Brown, M.F. (1990), High-Resolution Spectral Signature of Human Arterial
Plaque, United States Patent 4,940,055.
SEMINARS AND INVITED LECTURES (RECENT)
"Membrane Deformation Energy, Curvature Frustration, and Rhodopsin Function", 40th Annual Biophysical Society Meeting, Baltimore, Maryland (February, 1996) - invited lecture
"Membrane Structure and Dynamics Studied with NMR Spectroscopy", Scripps Research Institute, La Jolla, California (February, 1996) - lecture
"Molecular and Collective Dynamics of Membrane Bilayers: Evidence from NMR Relaxation", 40th Annual Biophysical Society Meeting, Baltimore, Maryland (February, 1996) - paper
"Surface Plasmon Resonance Studies of Membrane Proteins: Transducin Binding and Activation by Rhodopsin Monitored in Thin Membrane Films", 40th Annual Biophysical Society Meeting, Baltimore, Maryland (February, 1996) - paper
"Membrane Deformation Energy, Curvature Frustration, and Rhodopsin Function", 40th Annual Biophysical Society Meeting, Baltimore, Maryland (February, 1996) - paper
"Dynamics of Lipid Bilayers as Studied by Comparative Analysis of 13C and 2H NMR Relaxation Data" (presented by Alexander Nevzorov), 13th European Experimental N.M.R. Conference, Paris, France (May, 1996) - paper
"Modulation of Rhodopsin Function by Properties of the Membrane Bilayer", Department of Physical Biochemistry, University of Munich, Germany (August 1996) - lecture
"Structure and Dynamics of Membranes Studied with NMR Spectroscopy", Department of Physics, University of Würzburg, Germany (August 1996) - lecture
"Structure and Dynamics of Membranes Studied with NMR Spectroscopy", Department of Physics, University of Leipzig, Germany (August 1996) - lecture
"Membrane Structure and Dynamics Studied with NMR Spectroscopy", Department of Chemistry, University of Arizona, Tucson, Arizona (September, 1996) - lecture
"Deuterium NMR Spectroscopy of Membranes", NMR Brown Bag Lunch, Department of Chemistry, University of Arizona, Tucson, Arizona (October, 1996) - seminar
"Membrane Basis of the Visual Process", Biochemistry/Molecular and Cellular Biology Retreat, Department of Biochemistry, University of Arizona, Tucson, Arizona (October, 1996) - lecture
"NMR Relaxation Study of Lipid Membrane Dynamics", 41th Annual Biophysical Society Meeting, New Orleans, Louisiana (March, 1997) - paper
"Influences of Non-Lamellar Forming Lipids on Visual Function", 41th Annual Biophysical Society Meeting, New Orleans, Louisiana (March, 1997) - paper
"Rhodopsin-Lipid Interactions and Visual Function", Department of Physics, Free University of Berlin, Germany (June, 1997) - lecture
"Rhodopsin-Lipid Interactions and Visual Function", Department of Physical Biochemistry, University of Munich, Germany (June, 1997) - lecture
"Rhodopsin-Lipid Interactions and Visual Function", Institute of Physical
Chemistry, University of Freiburg, Germany (July, 1997) - lecture
"Deuterium NMR Spectroscopy of Membranes", Institute of Physical Chemistry,
University of Freiburg, Germany (July, 1997) - lecture
"Deuterium NMR Spectroscopy of Membranes", Department of Structural Biology, Jülich Research Center , Germany (July, 1997) - lecture
"Rhodopsin-Lipid Interactions and Visual Function", Department of Structural Biology, Jülich Research Center , Germany (July, 1997) - lecture
"Deuterium NMR Spectroscopy of Membranes", Department of Chemical Physics, University of Padua, Italy (July, 1997) - lecture
"Rhodopsin-Lipid Interactions and Visual Function", Department of Chemical Physics, University of Padua, Italy (July, 1997) - lecture
"Deuterium NMR Spectroscopy of Membranes", Institute of Chemical Physics,
University of Bologna, Italy (July, 1997) - lecture
"Deuterium NMR Spectroscopy of Membranes", Department of Chemistry,
University of Calabria, Italy (July, 1997) - lecture
"Deuterium NMR Spectroscopy of Membranes", Department of Chemistry, University of Florence, Italy (July, 1997) - lecture
"Rhodopsin-Lipid Interactions and Visual Function", Department of Biophysical Chemistry, Biocenter, University of Basel, Switzerland (July, 1997) - lecture
"Rhodopsin-Lipid Interactions and Visual Function", Department of Physics, University of Würzburg, Germany (July, 1997) - lecture
"Lipid-Protein Interactions and Rhodopsin Function in Membranes", Department of Bioengineering, Yokohama National University, Japan (December, 1997) - lecture
"Membrane Structure and Dynamics Studied with Solid-State NMR Spectroscopy", Department of Polymer Chemistry, Kyoto University, Japan (December, 1997) - lecture
"Solid-State NMR Spectroscopy and Lipid-Protein Interactions", Himeji Institute of Technology, Himeji Science Garden City, Japan (December, 1997) - lecture
"Solid-State NMR Spectroscopy of Membrane Proteins and Nucleic Acids", International Symposium for Design and Synthesis of Biofunctional Molecules, Tokyo, Japan (December, 1997) - invited lecture
"Lipid Dynamics from Orientation and Frequency Dependent Deuterium NMR Relaxation", 42nd Annual Biophysical Society Meeting, Kansas City, Missouri (February, 1998) - paper
"Deuterium NMR Lineshapes of Oriented DNA Films and Integral Membrane Proteins", 42nd Annual Biophysical Society Meeting, Kansas City, Missouri (February, 1998) - paper
"Deuterium NMR in Liquid Crystals and Membranes", VIII International Symposium on Magnetic Resonance in Colloid and Interface Science:, Namur, Belgium (May, 1998) - plenary lecture
"Lipid-Protein Interactions and Rhodopsin Function in Membranes", Division of Physical Chemistry 1, Center for Chemistry and Chemical Engineering, University of Lund, Sweden (June, 1998) - lecture
"Deuterium NMR Spectroscopy of Integral Membrane Proteins and Nucleic Acids", Max Planck-Institute for Biochemistry, Martinsreid, Germany (July, 1998) - lecture
"Membrane Elasticity and Lipid-Rhodopsin Interactions by Solid State NMR", Department of Chemistry and Program in Molecular Biophysics, University of Washington (October, 1998) - lecture
"Lipid Influences on the MI-MII Equilibrium o Membrane Bound Rhodopsin", 43rd Annual Biophysical Society Meeting, Baltimore, Maryland (February, 1999) - paper
"Chromophere Orientation in Bacteriorhodopsin from Deuterium NMR Spectra of Oriented Purple Membranes", 43rd Annual Biophysical Society Meeting, Baltimore, Maryland (February, 1999) - paper
"Lipid Bilayer Dynamics from Orientation and Frequency Dependent Deuterium NMR Relaxation", 43rd Annual Biophysical Society Meeting, Baltimore, Maryland (February, 1999)
"Lipid Bilayer Dynamics from Deuterium NMR Relaxation," 40th Experimental Nuclear Magnetic Resonance Conference, Orlando, Florida (March, 1999) - paper
"NMR of Aligned Membrane Proteins and Nucleic Acids," 40th Experimental Nuclear Magnetic Resonance Conference, Orlando, Florida (March, 1999) - plenary lecture
SCIENTIFIC PUBLICATIONS
Papers:
1.Brown, M.F., and Schleich, T. (1975), Circular Dichroism and Gel Filtration
Behavior of Subtilisin
Enzymes in Concentrated Solutions of Guanidine Hydrochloride, Biochemistry14,
3069-3074.
2.Brown, M.F., Miljanich G.P., Franklin, L.K., and Dratz, E.A. (1976),
1H-NMR Studies of Protein Lipid
Interactions in Retinal Rod Outer Segment Disc Membranes, FEBS Lett.
70, 56-60.
3.Brown, M.F., Miljanich, G.P., and Dratz, E.A. (1977), Interpretation
of 100- and 360-MHz Proton Magnetic
Resonance Spectra of Retinal Rod Outer Segment Disk Membranes, Biochemistry
16, 2640 2648.
4.Brown, M.F. Miljanich, G.P., and Dratz, E.A. (1977), Proton Spin-Lattice
Relaxation of Retinal Rod Outer
Segment Membranes and Liposomes of Extracted Phospholipids, Proc. Natl.
Acad. Sci. USA74, 1978-1982.
5.Brown, M.F., Omar, S., Raubach, R.A., and Schleich, T. (1977), Quenching
of The Tyrosyl and Tryptophyl
Fluorescence of Subtilisins Carslberg and Novo by Iodide, Biochemistry
16, 987-992.
6.Brown, M.F., and Schleich, T. (1977), Resolution of Independently
Titrating Spectral Components in the
Ultraviolet Circular Dichroism of Subtilisin Enzymes by Matrix Rank
Analysis, Biochim. Biophys. Acta485,
37-51.
7.Brown, M.F., and Seelig, J. (1977), Ion-Induced Changes in Head Group
Conformation of Lecithin
Bilayers, Nature (London) 269, 721-723.
8.Brown, M.F., and Seelig, J. (1978), Influence of Cholesterol on the
Polar Region of Phosphatidylcholine
and Phosphatidylethanolamine Bilayers, Biochemistry17, 381-384.
9.Omar, S., Brown, M.F., Silver, P., and Schleich, T. (1979), Histidyl
and Tyrosyl Residue Ionization Studies
of Subtilisin Novo, Biochim. Biophys. Acta 578, 261-268.
10.Brown, M.F., Seelig, J., and Haeberlen, U. (1979), Structural Dynamics
in Phospholipid Bilayers from
Deuterium Spin-Lattice Relaxation Time Measurements, J. Chem. Phys.
70, 5045-5053.
11.Brown, M.F. (1979), Deuterium Relaxation and Molecular Dynamics in
Lipid Bilayers, J. Magn. Res.35,
203-215.
12.Fleischer, S., Wang, C.-T., Hymel, L., Seelig, J., Brown, M.F., Herbette,
L., Scarpa, A., McLaughlin, A.C.,
and Blasie, J.K. (1979), Structural Studies of the Sarcoplasmic Reticulum
Membrane Using the
Reconstitution Approach, in Function and Molecular Aspects of Biomembrane
Transport (Quagliariello, E.,
et al., Eds.) Elsevier/North-Holland, Amsterdam, pp. 465-485 (invited
book chapter).
13.Deese, A.J., Dratz, E.A., and Brown, M.F. (1981), Retinal Rod Outer
Segment Lipids Form Bilayers in the
Presence and Absence of Rhodopsin: A 31P NMR Study, FEBS Lett. 124,
93-99.
14.Brown, M.F., and Davis, J.H. (1981), Orientation and Frequency Dependence
of the Deuterium Spin
Lattice Relaxation in Multilamellar Phospholipid Dispersions: Implications
for Dynamic Models of
Membrane Structure, Chem. Phys. Lett. 79, 431-435.
15.Brown, M.F., Deese, A.J., and Dratz, E.A. (1982), Proton, Carbon-13,
and Phosphorus-31 NMR Methods
for the Investigation of Rhodopsin-Lipid Interactions in Retinal Rod
Outer Segment Membranes, Methods
Enzymol.81, 709-728 (invited book chapter).
16.Brown, M.F. (1982), Theory of Spin-Lattice Relaxation in Lipid Bilayers
and Biological Membranes. 2H
and 14N Quadrupolar Relaxation, J. Chem. Phys. 77, 1576-1599.
17.Brown, M.F., Ribeiro, A.A., and Williams, G.D. (1983), New View of
Lipid Bilayer Dynamics >From 2H
and 13C NMR Relaxation Time Measurements, Proc. Natl. Acad. Sci. USA
80, 4325-4329.
18.Sefcik M.D., Schaefer, J., Stejskal, E.O., McKay, R.A., Ellena, J.F.,
Dodd, S.W., and Brown, M.F. (1983),
Lipid Bilayer Dynamics and Rhodopsin-Lipid interactions: New Approach
Using High Resolution
Solid-State 13C NMR. Biochem. Biophys. Res. Commun.114, 1048-1055.
19.Siminovitch, D.J., Brown, M.F., and Jeffrey, K.R. (1984), 14N NMR
of Lipid Bilayers: Effects of Ions
and Anesthetics, Biochemistry23, 2412-2420.
20.Siminovitch, D.J., Rance, M., Jeffrey, K.R., and Brown, M.F. (1984),
The Quadrupolar Spectrum of a Spin
I=1 in a Lipid Bilayer in the Presence of Paramagnetic Ions, J. Magn.
Res. 58, 62-75.
21.Brown, M.F. (1984), Theory of Spin-Lattice Relaxation in Lipid Bilayers
and Biological Membranes, J.
Chem. Phys. 80, 2808-2831.
22.Brown, M.F. (1984), Unified Picture for Spin-Lattice Relaxation of
Lipid Bilayers and Biomembranes, J.
Chem. Phys. 80, 2832-2836.
23.Trindle, C., Brown, M., and Newton, M.G. (1984), Use of Algebraic
Symbol-Manipulation Programs in
Chemical Research and Education, in Computer Education of Chemists
(P. Lykos, Ed.), Wiley, New York,
pp. 93-107.
24.Miljanich, G.P., Brown, M.F., Mabrey-Gaud, S., Dratz, E.A., and Sturtevant,
J.M. (1985), Thermotropic
Behavior of Retinal Rod Membranes and Dispersions of Extracted Phospholipids,
J. Membrane Biol. 85,
79-86.
25.Brown, M.F., and Williams, G.D. (1985), Membrane NMR: A Dynamic Research
Area, J. Biochem.
Biophys. Meth. 11, 71-81.
26.Williams, G.D., Beach, J.M., Dodd, S.W., and Brown, M.F. (1985),
Dependence of Deuterium
Spin-Lattice Relaxation Rates of Multilamellar Phospholipid Dispersions
on Orientational Order, J. Am.
Chem. Soc.107, 6868-6873.
27.Brown, M.F., Ellena, J.F., Trindle, D., and Williams, G.D. (1986),
Frequency Dependence of Spin Lattice
Relaxation Times of Lipid Bilayers, J. Chem. Phys.84, 465-470.
28.Ellena, J.F., Pates, R.D., and Brown, M.F. (1986), 31P NMR Spectra
of Rod Outer Segment and
Sarcoplasmic Reticulum Membranes Show No Evidence of Immobilized Components
Due to Lipid Protein
Interactions, Biochemistry25, 3742-3748.
29.Salmon, A., Dodd, S.W., Williams, G.D., Beach, J.M., and Brown, M.F.
(1986), Configurational Statistics
of Acyl Chains in Polyunsaturated Lipid Bilayers From 2H NMR, J. Am.
Chem. Soc. 109, 2600-2609.
30.Zajicek, J., Pearlman, J.D., Merickel, M.B., Ayers, C.R., Brookeman,
J.R., and Brown, M.F. (1987),
High-Resolution Proton NMR Spectra of Human Arterial Plaque, Biochem.
Biophys. Res. Commun. 149,
437-442.
31.Pearlman, J.D., Zajicek, J., Merickel, M.B., Carman, C.S., Ayers,
C.R., Brookeman, J.R., and Brown, M.F.
(1988), High-Resolution 1H NMR Spectral Signature From Human Atheroma,
Magn. Reson. Med. 7,
262-279.
32.Wiedmann, T.S., Pates, R.D., Beach, J.M., Salmon, A., and Brown,
M.F. (1988), Lipid-Protein Interactions
Mediate Photochemical Function of Rhodopsin, Biochemistry 27, 6469-6474.
33.Merickel, M.B., Carman, C.S., Brookeman, J.R., Mugler, J., Brown,M.F.,
and Ayers, C. (1988),
Identification and 3-D Quantification of Atherosclerosis Using Magnetic
Resonance Imaging, Compt. Biol.
Med.18, 89-102.
34.Brown, M.F., Dodd, S.W., and Salmon, A. (1989), Deuterium NMR Spectroscopy
of Saturated and
Polyunsaturated Lipid Bilayers, in Highlights of Modern Biochemistry
(Kotyk, A., et al., Eds.) VSP
International, Zeist, pp. 725-734.
35.Brown, M.F., Salmon, A., Henriksson, U., and Söderman, O. (1990),
Frequency Dependent 2H N.M.R.
Relaxation Rates of Small Unilamellar Vesicles, Mol. Phys.69, 379-383.
36.Brown, M.F., and Söderman, O. (1990), Orientational Anisotropy
of Nuclear Spin Relaxation in
Phospholipid Membranes, Chem. Phys. Lett.167, 158-164.
37.Jansson, M., Thurmond, R.L., Trouard, T.P., and Brown, M.F. (1990),
Magnetic Alignment and
Orientational Order of Dipalmitoylphosphatidylcholine Bilayers Containing
Palmitoyllysophosphatidylcholine, Chem. Phys. Lipids54, 157-170.
38.Gibson, N.J., and Brown, M.F. (1990), Influence of pH on the MI-MII
Equilibrium of Rhodopsin in
Recombinant Membranes, Biochem. Biophys. Res. Commun. 169, 1028-1034.
39.Brown, M.F. (1990), Anisotropic Nuclear Spin Relaxation of Cholesterol
in Phospholipid Bilayers, Mol.
Phys. 71, 903-908.
40.Thurmond, R.L., Lindblom, G., and Brown, M.F. (1990), Influences
of Membrane Curvature in Lipid
Hexagonal Phases Studied by Deuterium NMR Spectroscopy, Biochem. Biophys.
Res. Commun. 173,
1231-1238.
41.Thurmond, R.L., Dodd, S.W., and Brown, M.F. (1991), Molecular Areas
of Phospholipids as Determined
By 2H NMR Spectroscopy: Comparison of Phosphatidylethanolamines and
Phosphatidylcholines, Biophys.
J.59, 108-113.
42.Barry, J.A., Trouard, T.P., Salmon, A., and Brown, M.F. (1991), Low
Temperature 2H NMR Spectroscopy
of Phospholipid Bilayers Containing Docosahexaenoyl (22:63) Chains,
Biochemistry30, 8386-8394.
43.Rajamoorthi, K., and Brown, M.F. (1991), Bilayers of Arachidonic
Acid Containing Phospholipids
Studied By 2H and 31P NMR Spectroscopy, Biochemistry30, 4204-4212.
44.Altbach, M.I., Mattingly, M., Brown, M.F., and Gmitro, A.F. (1991),
Magnetic Resonance Imaging of
Lipid Deposits in Human Atheroma via a Stimulated-Echo Diffusion Technique,
Magn. Reson. Med. 20,
319-326.
45.Gibson, N.J., and Brown, M.F. (1991), Membrane Lipid Influences on
the Energetics of the MI and MII
Conformational States of Rhodopsin Probed by Flash Photolysis, Photochem.
Photobiol. 54, 985-992.
46.Thurmond, R.L., Lindblom, G., and Brown, M.F. (1991), Effect of Bile
Salts on Monolayer Curvature of a
Phosphatidylethanolamine/Water Model Membrane System, Biophys. J. 60,
728-732.
47.Gibson, N.J., and Brown, M.F. (1991), Role of Phosphatidylserine
in the MI-MII Equilibrium of
Rhodopsin, Biochem. Biophys. Res. Commun.176, 915-921.
48.Lamparski, H., Liman, U., Barry, J.A., Frankel, D.A., Ramaswami,
V., Brown, M.F., and O'Brien, D.F.
(1992), The Photoinduced Destabilization of Liposomes, Biochemistry
31, 685-694.
49.Trouard, T.P., Alam, T.M., Zajicek, J., and Brown, M.F. (1992), Angular
Anisotropy of 2H NMR Spectral
Densities in Phospholipid Bilayers Containing Cholesterol, Chem. Phys.
Lett. 189, 67-75.
50.Barry, J.A., Lamparski, H., Shyamsunder, E., Osterberg, F., Cerne,
J., Brown, M.F., and O'Brien, D.F.
(1992), 31P NMR and X-Ray Diffraction Study of the Effect of Photopolymerization
on Lipid
Polymorphism, Biochemistry31, 10114-10120.
51.Jansson, M., Thurmond, R.L., Barry, J.A., and Brown, M.F. (1992),
Deuterium NMR Study of
Intermolecular Interactions in Lamellar Phases Containing Palmitoyllysophosphatidycholine,
J. Phys. Chem.
96, 9532-9544.
52.Alexander, A.A., Pytlewski, V.T., Brown, M.F., and Gmitro, A.F. (1992),
Detection of Atherosclerosis via
Magnetic Resonance Imaging, Proc. SPIE (Society of Photooptical Engineers)1642,
26-33.
53.Brown, M.F., and Gibson, N.J. (1992), Biological Function of Docosahexaenoic
Acid in the Retinal Rod
Disk Membrane, in Essential Fatty Acids and Eicosanoids (Sinclair,
A., and Gibson, R., Eds.), American Oil
Chemist's Society Press, Champaign, Illinois, pp. 134-138 (invited).
54.Gibson, N.J., and Brown, M.F. (1993), Lipid Headgroup and Acyl Chain
Composition Modulate the
MI-MII Equilibrium of Rhodopsin in Recombinant Membranes, Biochemistry
32, 2438-2454.
55.Thurmond, R.L., Lindblom, G., and Brown, M.F. (1993), Curvature,
Order, and Dynamics of Lipid
Hexagonal Phases Studied by Deuterium NMR Spectroscopy, Biochemistry32,
5394-5410.
56.Thurmond, R.L., Otten, D., Brown, M.F., and Beyer, K. (1993), Structure
and Packing of
Phosphatidylcholines in Lamellar and Hexagonal Liquid Crystalline Mixtures
with a Nonionic Detergent: A
Wide Line NMR Study, J. Phys. Chem 98, 972-983.
57.Trouard, T.P., Alam, T.M., Job, C., and Brown, M.F. (1994), Angular
Dependence of Deuterium
Spin-Lattice Relaxation of Dilaurylphosphatidylcholine in the Liquid-Crystalline
Phase, J. Chem. Phys. 101,
5229-5261.
58.Job. C., Pearson, R., and Brown, M. F. (1994), A Personal Computer-Based
NMR Spectrometer, Rev.
Sci. Inst. 65, 3354-3362.
59.Salamon, Z., Wang, Y., Brown, M. F., MacLeod, A., and Tollin, G.
(1994), Conformational Changes in
Rhodopsin Probed by Surface Plasmon Resonance Spectroscopy, Biochemistry
33, 13706-13711.
60.Brown, M. F. (1994), Modulation of Rhodopsin Function by Properties
of the Membrane Bilayer, Chem.
Phys. Lipids 73, 159-180 (invited review).
61.Schroeder, T. B., Job, C., Brown, M. F., and Glass, R. S. (1995),
Indirect Detection of Selenium 77 in
Nuclear Magnetic Resonance Spectra of Organoselenium Compounds, Mag.
Reson. Chem. 33, 191-195.
62.Brown, M. F., and Chan, S. I. (1995), Bilayer Membranes: Deuterium
& Carbon-13 NMR, in
Encylcopedia of Nuclear Magnetic Resonance (Grant, D. M., and Harris,
R. K., Eds.), Wiley, New York, pp.
871-885 (invited book chapter).
63. Zajicek, J., Ellena, J. F., Williams, G. D., Khadim, M., and Brown,
M. F. (1995), Molecular Dynamics of
Vesicles of Unsaturated Phosphatidylcholines Studied by 13C NMR Spin-Lattice
Relaxation, Collect.
Czech. Chem. Commun.60, 719-735.
64.Brown, M. F. (1996), Membrane Structure and Dynamics Investigated
with NMR Spectroscopy, in
Membrane Structure and Dynamics (Merz, K. M., and Roux, B., Eds.),
Birkhäuser, Boston, pp. 175-252
(invited book chapter).
65.Salamon, Z., Wang, Y., Soulages, J. L., Brown, M. F., and Tollin,
G. (1996), Surface Plasmon Resonance
Spectroscopy Studies of Membrane Proteins: Transducin Binding and Activation
by Rhodopsin Monitored in
Thin Membrane Films, Biophys. J. 71, 283-294.
66.Job, C., Zajicek, J., and Brown, M. F. (1996), Fast Field Cycling
Nuclear Magnetic Resonance
Spectrometer, Rev. Sci. Instr. 67, 2113-2122.
67.Nevzorov, A. A., Trouard, T. P., and Brown, M. F. (1997), Correlation
Functions for Lipid Membrane
Fluctuations Obtained from NMR Spectroscopy, Phys. Rev. E55, 3276-3282.
68.Nevzorov, A. A., and Brown, M. F. (1997), Dynamics of Lipid Bilayers
from Comparative Analysis of
13C and 2H NMR Relaxation Data as a Function of Frequency and Temperature,
J. Chem. Phys.107,
10288-10310.
69.Brown, M. F. (1997), Influences of Nonlamellar-Forming Lipids on
Rhodopsin, in Current Topics in
Membranes (Epand, R. M., Ed.), Academic Press, San Diego, pp. 285-356
(invited book chapter).
70.Schroeder, T. B., Job, C., Brown, M. F., Glass, R. S., You, N., and
Block, E. (1997), 1H-{125Te} Indirect
Detection in Nuclear Magnetic Resonance Spectra of Organotellurium
Compounds, Mag. Reson. Chem. 35,
752-756.
71.Nevzorov, A. A., Moltke, S., and Brown, M. F. (1998), Structure of
the A-Form and B Form of DNA from
Deuterium NMR Lineshape Simulation, J. Am. Chem. Soc. 120, 4798 4805.
72.Nevzorov, A. A., Trouard, T. P., and Brown, M. F. (1998), Lipid Bilayer
Dynamics from Simultaneous
Analysis of Orientation and Frequency Dependence of Deuterium Spin
Lattice and Quadrupolar Order
Relaxation, Phys. Rev. E 58, 2259-2281.
73.Moltke, S., Nevzorov, A. A., Sakai, N., Wallat, I., Job, C., Nakanishi,
K., Heyn, M. P., and Brown, M. F.
(1998), Chromophore Orientation in Bacteriorhodopsin Determined from
the Angular Dependence of
Deuterium Nuclear Magnetic Resonance Spectra of Oriented Purple Membranes,
Biochemistry 37,
11821-11835.
74.Kasal, A., Budesinsky, M., Pelnar, J., Bruck, M. A., and Brown, M.
F. (1999), Structures and Synthesis of
A-Homo-B,19-dinorsteroids by X-Ray Crystallography and NMR Spectroscopy,
Collect. Czech. Chem.
Commun., in press.
75.Brown, M. F., and Nevzorov, A. A. (1999), 2H-NMR in Liquid Crystals
and Membranes, Colloids and
Surfaces, in press (invited review).
76.Hetzer, M., Gutberlet, T., Brown, M. F., Camps, X., Vostrovsky, O.,
Schönberger, H., Hirsch, A., and
Bayerl, T. M. (1999), Thermotropic Behavior of Lipophilic Derivatized
[60]fullerenes Studied by Deuterium
NMR, X-ray diffraction, and Microcalorimetry, J. Phys. Chem. A 103,
637-642.
77.Moltke, S., Wallat, I., Sakai, N., Nakanishi, K., Brown, M. F., and
Heyn, M. P. (1998), The Angles
Between the C1?, C5?, and C9?Methyl Bonds of the Retinylidene Chromophore
and the Membrane Normal
Increase in the M Intermediate of Bacteriorhodopsin: Direct Determination
with Solid-State 2H-NMR,
Biochemistry, in press.
78.Nevzorov, A. A., Moltke, S., Heyn, M. P., and Brown, M. F. (1999),
Solid-State NMR Lineshapes of
Uniaxially Oriented Immobile Systems, J. Am. Chem. Soc. 121, 7636-7643.
79.Trouard, T. P., Nevzorov, A. A., Alam, T. M., Job, C., Zajicek, J.,
and Brown, M. F. (1999), Influence of
Cholesterol on Dynamics of Dimyristoylphosphatidylcholine Bilayers
as Studied by Deuterium NMR
Relaxation, J. Chem. Phys. 110, 8802-8818.
80.Salamon, Z., Brown, M. F., and Tollin, G. (1999), Plasmon Resonance
Spectroscopy: Probing Molecular
Interations within Membranes, Trends Biochem. Sci. 24, 213-219 (invited
review).
Book Reviews:
1. Brown, M.F. (1983), Review of "Nuclear Magnetic Resonance and Its
Applications to Living Systems" by
David G. Gadian (Oxford University Press, 1982), J. Am. Chem. Soc.
105, 5184.
2.Brown, M.F. (1990), Review of "Biophysical Chemistry of Membrane Functions"
by Arnost Kotyk, Karel
Janacek, and Jiri Koryta (Wiley-Interscience, 1988), J. Am. Chem. Soc.
112, 8220.
3.Brown, M.F. (1997), Review of "NMR as a Structural Tool for Macromolecules.
Current Status and Future
Directions" by B. D. Nageswara Rao and Marvin D. Kemple, J. Am. Chem.
Soc. 119, 9937 9938.