Analytical Spectroscopy/Mass Spectrometry/Laboratory Automation
"The latest technological advances in electronics, physics, optics,
acoustics, mechanical engineering and computer science are being
utilized to develop new and improved analytical spectrochemical
techniques. A multifaceted but strongly interlocking program
designed to elucidate fundamental phenomena occurring in systems
employed for spectrochemical analysis is currently underway.
Fundamental theoretical knowledge obtained in these studies is being
applied toward the development of more accurate and sensitive
analytical techniques.
Over the past fifteen years, focal plane array
detectors have brought an amazing revolution to analytical
spectroscopy, providing increased sensitivity, dynamic range, and
improved background correction. New generations of these detectors
are being developed and applied to a variety of spectroscopic
techniques, including fluorescence, phosphorescence, Raman, and
atomic emission analysis. Raman spectroscopy utilizing advanced
instrumental concepts, including far-UV laser excitation, is being
investigated. Applications including pharmaceutical analysis, gem
and mineral identification, and advanced techniques for process
control are under study. Emphasis is currently being placed on
approaches for rapid, sensitive simultaneous analysis of multiple
trace level species.
A variety of projects are under way in the area of
mass spectrometry, including the development of improved ion sources
and sample introduction techniques. Advanced vacuum ultraviolet
lasers are being utilized to provide selective photoionization of
specified molecules and applied to chemotherapy research.
A program to develop new array detector technologies for mass
spectrometry and ion mobility spectrometry is rapidly advancing.
Current results promise to revolutionize detection schemes for both
techniques.
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"The Impact of Array Detectors for Raman Spectroscopy," Stephen Denson, Carolyn Pommier, and M. Bonner Denton, J. Chem. Ed., Vol. 84, No. 1, 67-74 (2007).
"Characterization of a Second-Generation Focal-Plane Camera Coupled to an Inductively Coupled Plasma Mattauch-Herzog Geometry Mass Spectrograph," Gregory D. Schilling, Francisco J. Andrade, James H. Barnes IV, Roger P. Sperline, M. Bonner Denton, Charles J. Barinaga, David W. Koppenaal, and Gary M. Hieftje, Analytical Chemistry 78, 4319-4325 (2006).
""Electrothermal vaporization coupled with inductively coupled plasma array detector mass spectrometry for the multielement analysis of AI2O3 ceramic powders," Birgit U. Peschel, Francisco J. Andrade, William C. Wetzel, Gregory D. Schilling, Gary M. Hieftje, Jose A. C. Broekaert, Roger P. Sperline, M. Bonner Denton, Charles J. Barinaga, and David W. Koppenaal, Spectrochimica Acta Part B 61 pp. 42-49 (2006).
""Advanced Detector and Optical Fabrication Technologies for Implementing Improved Spectroscopic Instrumentation: The Use of a CTIA Detector in Ion Mobility Spectrometry," M. Bonner Denton, Andrew K. Knight, Roger P. Sperline, and Christopher A. Gresham,in Scientific Detectors for Astronomy 2005, Explorers of the Photon Odyssey, Series: Astrophysics and Space Science Library, Jenna E. Beletic, James W. Beletic, and Paola Amico, Eds.; Springer, Dordrecht, The Netherlands, Vol. 336, pp. 207-216 (2006).
"Read-noise Characterization of Focal Plane Array Detectors via Mean-Variance Analysis," R. P. Sperline, A. K.
Knight, C. A. Gresham, D. W. Koppenaal, G. M. Hieftje, and M. B. Denton, Applied Spectroscopy 59-11, 1315-1323 (2005).
"Mass Spectrometry Detectors," D.W. Koppenaal, C.J. Barinaga, M.B. Denton, R.P. Sperline, G.M. Hieftje, G.D.
Schilling, F.J. Andrade, and J. A. Barnes IV, Analytical Chemistry, November 1, 2005, 419A-427A.
"Raman and X-Ray Investigations of LiFeSi2O6 Under Pressure," Carolyn J. S. Pommier, Robert T. Downs, Marilena Stimpfl, Günther J. Redhammer, and M. Bonner Denton, J. Raman Spectroscopy 36 (9), 864-871 (2005).
"“Advances in Array Detectors for X-ray Diffraction Techniques,” Quentin S. Hanley and M. Bonner Denton, J. Synchrotron Radiation 12, 618-625 (2005).
"Advances in Array Detectors for X-ray Diffraction Techniques," Quentin S. Hanley and M. Bonner Denton, J. Synchrotron Radiation 12, 618-625 (2005).
"Evaluation of a hydrogen laser vacuum ultraviolet source for photoionization mass spectrometry of
pharmaceuticals," Jeffrey W. Finch, Kevin A. Toerne, Karl H. Schram, and M. Bonner Denton, Rapid Communications in Mass Spectrometry 19, 15-22 (2005).
"Simultaneous Multichannel Mass-Specific Detection for High-Performance Liquid Chromatography Using an Array Detector Sector-Field Mass Spectrometer," James H. Barnes IV, Gregory D. Schilling, Steven F. Stone, Roger P. Sperline, M. Bonner Denton, Erick T. Young, Charles J. Barinaga, David W. Koppenaal and Gary M. Hieftje, Analytical & Bioanalytical Chemistry 380, 227-234 (2004).
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