Dominic V. McGrath
BS 1986, Yale University
Ph.D. 1992, California Institute of Technology
1997, Research Corporation Cottrell Scholar
1997, NSF CAREER Award
1999, Camille Dreyfus Teacher Scholar Award

office CSML 630
phone (520) 626-4690
fax (520) 621-8407

Organic, Organometallic, and Polymer Chemistry

Our research program involves the use of organic synthesis for the design, development, and application of new concepts in macromolecular, supramolecular, and materials chemistry. Our research efforts span a number of areas in the chemical sciences and include studies of (a) chiral dendritic macromolecules and the effect of chiral subunits on dendrimer conformation, (b) photochromic dendrimers and linear polymers which undergo structural changes in response to visible light, (c) liquid crystalline materials based on dendritic and photochromic mesogens, and (d) synthesis of new ligands based on saturated nitrogen heterocycles.

We have a continuing interest in the effect of structural perturbations on the properties and functional of dendritic macromolecules. Part of this research addresses the design, synthesis, and study of dendrimeric materials containing chiral moieties in the interior for influencing the conformational order of these 3-dimensional macromolecules. An ultimate goal is to develop materials active for the selective clathration of small guest molecules. Potential applications include chemical separations, sensor technology, environmental remediation, and asymmetric catalysis.

We have recently developed several new classes of dendritic materials containing photochromic subunits. As nature uses light energy to alter function in photoresponsive systems such as photosynthesis, vision, phototropism, and phototaxis, we use light energy to drive gross topological or constitutional changes in fundamentally new dendritic architectures with precisely placed photoresponsive subunits. In short, we can drive dendrimer properties with light stimuli. We have developed two entirely new classes of photoresponsive dendritic macromolecules: (1) Photochromic Dendrimers, and (2) Photolabile Dendrimers. We anticipate that switchable and degradable dendrimers of this type will have application in small molecule transport systems based on their ability to reversibly encapsulate guest molecules. We are continuing to develop these materials as potential transport hosts and photoresponsive supramolecular assemblies.



"Azobenzene-Containing Dendrimers." Villavicencio, O.F.; McGRATH, D.V. Advances in Dendritic Macromolecules 2002, 5, 1-44.

"Microstructure of amphiphilic monodendrons at the air-water interface," Larson, K.;Vaknin, D.;Villavicencio, O.;McGrath, D.;Tsukruk, V. V. J. Phys. Chem. 2002, ASAP.

"Molecular Packing of Amphiphiles with Crown Polar Heads at the Air-Water Interface," Larson, K.;Vaknin, D.;Villavicencio, O.;McGrath, D.;Tsukruk, V. V. J. Phys. Chem. B 2002, 106, 7246-7251.

"Synthesis of Photolabile Dendrimer Cores," Kevwitch, R.M.; McGrath, D.V. Synthesis 2002, 1171-1176.

"Langmuir-Blodgett monolayers from lower generation amphiphilic monodendrons," Peleshanko, S.; Sidorenko, A.; Larson, K.; Villavicencio, O.; Ornatska, M.; McGrath, D.V.; Tsukruk, V.V. Thin Solid Films 2002, 406, 233-240.

"Low generation photochromic monodendrons on a solid surface," Sidorenko, A.; Houphouet-Boigny, C.; Villavicencio, O.; McGrath, D. V.; Tsukruk V. V. Thin Solid Films 2002, 410, 147-158.

"Hydrobenzoin-Based Rigid Chiral Polymer." Bieging, A.R.; Liao, L.-X.; McGrath, D.V. Chirality 2002, 14, 258-263.

"Photochromic Dendrimers Containing Six Azobenzenes." Liao, L.-X.; Junge, D.M.; McGRATH, D. V. Macromolecules. 2002, 35, 319-322.

"Intralayer Reorganization of Photochromic Molecular Films." Tsukruk, V.V.; Luzinov, I.; Larson, K.; Li., S.; McGrath, D.V. J. Mater. Sci. Lett. 2001, 20, 873-876.

"Photoresponsive Langmuir Monolayers from Azobenzene-Containing Dendrons." Sidorenko, A.; Houphouet-Boigny, C.; Villavicencio, O.; Hashemzadeh, M.; McGRATH, D. V.; Tsukruk, V. V. Langmuir. 2000, 16, 10569-10572.

"Effect of Macromolecular Isomerism on the Photomodulation of Dendrimer Properties." Li, S.; McGrath, D.V. J. Am. Chem. Soc. 2000, 122, 6795-6796.

"Synthesis and Chiroptical Analysis of Optically Active Chiral Shell Dendrons." Junge, D.M.; Wu, M.-J.; McElhanon, J.R.; McGrath, D.V. J. Org. Chem. 2000, 5306-5314.

"Toward Chiral Polyhydroxylated Dendrimers. Preparation and Chiroptical Properties." McElhanon, J.R.; McGrath, D.V. J. Org. Chem. 2000, 65, 3525.

"Photolabile Dendrimers Using o-Nitrobenzyl Ether Linkages." Smet, M.; Liao, L.; Dehaen, W.; McGrath, D.V. Organic Lett. 2000, 2, 511-513.

"Photoresponsive Azobenzene-Containing Dendrimers with Multiple Discrete States." Junge, D.M.; McGrath, D.V. J. Am. Chem. Soc. 1999, 121, 4912-4913.

"Mild and Convenient Oxidation of Aromatic Heterocyclic Primary Alcohols by 4-Acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium Perchlorate." Kernag, C.A.; Bobbitt, J.M.; McGrath, D.V. Tetrahedron Lett. 1999, 40, 1635-1636.

"Driving dendrimers with light: dendrimers with azobenzene central linkers." McGrath, D.V.; Junge, D.M. Macromol. Symp. 1999, 137, 57-65.

"Synthesis of Optically Active Chiral Shell Dendrons." Junge, D.M.; McGrath, D.V. Tetrahedron Lett. 1998, 39, 1701-1704.

"Constitution, Configuration, and the Optical Activity of Chiral Dendrimers." McElhanon, J.R.; McGrath, D.V. J. Am. Chem. Soc. 1998, 120, 1647-1656.

"Photoresponsive Dendrimers." Junge, D.M.; McGRATH, D.V. Chem. Commun. 1997, 857-858.

date: Sat, 15 Dec 2001 06:14:59 GMT
time: Sat, 15 Dec 2001 06:14:59 GMT