Faculty Profile

Faculty Profile of Mark (Marty) Pagel

Mark (Marty) Pagel

Associate Professor

Email: mpagel@u.arizona.edu
Building: Can Cen 4949
Phone: 520-404-7049

Honors


  • Sydney E. Salmon Distinguished Junior Investigator Award, Arizona Cancer Center, Tucson, AZ, 2010
  • Case School of Engineering Graduate Teaching Award, CWRU, Cleveland, OH, 2006
  • Young Investigator Award, Contrast Media Research 2005 Symposium, 2005
  • Early Career Recognition Award, Pharmacia Corp., St. Louis, MO, 2003
  • John C. Sowden Prize in Chemistry, Washington University, St. Louis, MO, 1988

Education and Appointments


  • B.A., Chemistry 1988, Washington University, St. Louis, MO
  • B.A., Biology 1988, Washington University, St. Louis, MO
  • PhD, Chemistry 1993, University of California, Berkeley CA

Research Interests


  • Biochemistry
  • Physical
  • Bioanalytical
  • Chemical Biology
  • Spectroscopy/molecular Structure

Research Summary

The Contrast Agent Molecular Engineering Laboratory (CAMEL) develops chemical agents that change the contrast of biomedical images. These contrast agents are designed to respond to molecular biomarkers of biological processes and pathologies. This molecular imformation is used to predict response to therapy before the therapy is applied, monitor the delivery of therapy to targeted tissues, and evaluate the early-stage effects of the therapy. This "theragnostics" approach integrates non-invasive imaging diagnostics with therapy, which may provide personalizd medicine for a patient.

CAMEL primarily focuses on the development of contrast agents for Magnetic Resonance Imaging (MRI). In particular, CAMEL has developed a new type of MRI contrast agent that can detect enzymes and metabolites through PARAmagnetic Chemical Exchange Saturation Transfer (PARACEST). CAMEL has also developed methods that rapidly synthesize contrast agents that are attached to peptides, for use in MRI, PET, and SPECT imaing studies. CAMEL also has interests in developing optical imaging contrast agents, and agents that can be detected by multiple imaging modalities.

CAMEL is affiliated with the Biomedical Engineering Interdisciplinary Program, the Department of Chemistry, the Arizona Cancer Center, the Arizona Research Laboratories, the Advanced Research Institute for Biomedical Imaging (ARIBI), and the Institute for Collaborative BioResearch (BIO5) at the University of Arizona in Tucson, AZ. These afiliations reflect the interdisciplinary resarch approach undertaken by CAMEL and the supportive environment for biomedical research at the University of Arizona. For these reasons, the CAMEL has found an ideal home in the desert!

Research interests: Biophysical Chemistry, Biomedical Imaging, Cancer Biology

Selected Publications

1. Yoo B, Pagel MD. A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe. Tetrahedron Lett, 2006, 47:7327-7330.

2. Yoo B, Pagel MD. A PARACEST MRI contrast agent to detect enzyme activity. J. Am. Chem. Soc., 2006, 128(43):14032-14033.

3. YooB, Pagel MD. Peptidyl Molecular Imaging Contrast Agents Using a New Solid Phase Peptide Synthesis Approach. Bioconj. Chem., 2007,18:903-911.

4. Yoo B, Raam M, Rosenblum R, Pagel MD. Enzyme-responsive PARACEST MRI contrast agents: A new biomedical imaging approach for studies of the proteasome. Contrast Media Molec. Imag., 2007, 2:189-198.

5. Liu G, Lu Y, Pagel MD. Design and characterization of new irreversible responsive PARACEST MRI contrast agent that detects nitric oxide. Magn. Reson. Med., 2007, 58:1249-1256.

6. Yoo B, Pagel MD. An overview of responsive MRI contrast agents for molecular imaging. Front. Bioscience, 2008, 13:1733-1752.

7. Sheth VR, van Heeckeren RC, Wilson AG, van Heeckeren AM, Pagel MD, Monitoring Infection and Inflammation in Murine Models of Cystic Fibrosis with Magnetic Resonance Imaging, J Magn Reson Imaging, 2008, 28(2):527-532.

8. Liu G, Ali, M, Yoo B, Griswold MA, Tkach JA, Pagel MD. PARACEST MRI With Improved Temporal Resolution. Magn Reson Med, 2009, 61:399-408.

9. Ali MM, Yoo B, Pagel MD. Tracking the relative in vivo pharmacokinetics of nanoparticles with PARACEST MRI. Molec Pharmaceutics, 2009, 6(5):1409–1416.

10. Yoo B, Sheth V, Pagel MD. An amine-derivatized, DOTA-loaded polymeric support for Fmoc Solid Phase Peptide Synthesis. Tet Lett, 2009, 50:4459–4462.

11. Ali MM, Liu G, Shah T, Flask CA, Pagel MD. Using Two Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Contrast Agents for Molecular Imaging Studies. Acc Chem Res, 2009, 42(7):915-924.

12. Shah T, Lu L, Dell K, Pagel MD, Griswold M, Flask CA. CEST-FISP: A Novel Technique for Rapid Chemical Exchange Saturation Transfer (CEST) MRI at 7T. Magn Reson Med 2011, 65:432–437.

13. Li Y, Sheth VR, Liu G, Pagel MD. A self-calibrating PARACEST MRI contrast agent that detects esterase enzyme activity. Contrast Media Molec Imaging, 2011, in press.

14. Liu G, Li Y, Sheth VR, Pagel MD. Imaging in vivo extracellular pH with a Single PARACEST MRI Contrast Agent. Molecular Imaging, 2011, in press.

Home