Faculty
Faculty participating in the program hold appointments in either the Department of Chemistry and Biochemistry, or the Department of Pharmacology and Toxicology.
| Faculty | Research Interests |
|---|---|
| Craig A. Aspinwall Chemistry/Biochemistry |
Cellular Function at the Interface of Analytical Chemistry and Cell Physiology |
| Vahe Bandarian Chemistry/Biochemistry |
Biosynthesis of secondary metabolites; mechanistic enzymology |
| Michael Brown Chemistry/Biochemistry |
NMR spectroscopy; membrane proteins and lipid bilayers; receptors and biological signaling; vision |
| Eli Chapman Pharmacology and Toxicology |
Protein-guided therapeutic discovery; Chemical biology to study p97 biochemistry and biophysics; Small-molecule based therapeutic discovery and development |
| Pascale Charest Chemistry/Biochemistry | Signaling mechanisms and directed cell motility |
| Matthew Cordes Chemistry/Biochemistry |
Structural Evolution and Conformational Switching in Proteins |
| Indraneel Ghosh Chemistry/Biochemistry |
Signal Transduction Pathways, Anti-Cancer Agents and Protein Based Biosensors |
| Richard S. Glass Chemistry/Biochemistry |
Mechanistic, Synthetic and Structural Chemistry |
| Andrew Hausrath Chemistry/Biochemistry |
Constructing quantitative theories about biomolecules and their assemblies, and testing these theories with biophysical and structural techniques |
| Michael Heien Chemistry/Biochemistry | Measuring neurotransmitters and neuromodulators. Specifically to figure out how chemicals affext individual neurons and behavior. The goal of his research is to understand the molecular mechanisms behind synapse formation, the role of supporting cells in modulation of neurotransmission, and how these work to regulate behavior. |
| Nancy Horton Chemistry/Biochemistry |
Macromolecular structure and function; X-ray crystallography |
| Victor J. Hruby Chemistry/Biochemistry |
Asymmetric Synthesis; Biologically Active Peptides/Mimetics; Conformation-Activity Relationships |
| Christopher Hulme Chemistry/Biochemistry |
Enabling chemistries and platform technologies for the construction of targeted small molecule libraries that span possible applications across multiple target families |
| Laurence H. Hurley Pharmacology and Toxicology |
Development of antitumor agents |
| John Jewett Chemistry/Biochemistry |
Chemical virology - Developing chemical tools to study dengue virus |
| Serrine Lau Pharmacology and Toxicology |
Environmental causes of disease; Mechanisms of prostanoid mediated cytoprotection against environmental chemical-induced toxicity; Development of mass spectrometric-based proteomics approaches to study chemical-induced protein modifications which impact on specific cellular functions. |
| Hong-Yu Li Pharmacology and Toxicology |
|
| Eugene A. Mash, Jr. Chemistry/Biochemistry |
Organic Synthesis; Medicinal Chemistry; Chemical Toxicology |
| Megan M. McEvoy Chemistry/Biochemistry |
Structure/Function of Protein Complexes |
| Katrina M. Miranda Chemistry/Biochemistry |
Chemical Biology of Nitrogen Oxides; New Detection Techniques and Donors of Nitrogen Oxides; Drug Development |
| Osamu Miyashita Chemistry/Biochemistry |
Theoretical and Computational Biophysics, Molecular Dynamics Simulations, Protein Electron Transfer, Protein Allostery |
| William R. Montfort Chemistry/Biochemistry |
Protein structure, function and dynamics; X-ray crystallography |
| Jon Njardarson Chemistry/Biochemistry | Organic synthesis, medicinal chemistry and drug development |
| Mark Pagel ARL/Cancer Center |
Magnetic Resonance Imaging; assessments of cancer and anticancer therapeutics |
| Robin L. Polt Chemistry/Biochemistry |
Cell-surface Carbohydrates |
| S. Scott Saavedra Chemistry/Biochemistry |
Interfacial Optics, Biofilms, Biosensors |
|
Steve Schwartz Chemistry/Biochemistry |
Understanding the atomic reaction coordinate of chemical reactions when catalyzed by enzymes and the function of complex protein motor assemblies. |
| Catharine L. Smith Pharmacology and Toxicology |
Epigenetic mechanisms of gene expression, their regulation through signaling pathways and modulation by anti-cancer drugs |
|
Deakyu Sun |
Regulation of gene expression with chemicals |
| Florence Tama Chemistry/Biochemistry |
Computational Structural Biology, Function and Dynamics of Macromolecular Assemblies, Multi-Scale Modeling, Methods Development to Interpret Experimental Data |
| Elisa Tomat Chemistry/Biochemistry | Biological inorganic chemistry of oxidative stress, wound healing, cell proliferation and cancer |
| Tsu-shuen Tsao Chemistry/Biochemistry |
Obesity and type II diabetes mellitus; Hormonal regulation of energy homeostasis; Signal transduction pathways involved in cellular and whole body energetics; Structure function relationship of adipocyte-derived hormones |
| Koen Visscher Physics |
Molecular Motors
|
| Georg Wondrak Pharmacology and Toxicology |
Molecular pathways of skin photocarcinogenesis that involve cellular photooxidative and carbonyl stress; Developing chemical reagents into potent drugs that target reactive chemical intermediates |
| Danzhou Yang Pharmacology and Toxicology |
Structure and Function of DNA and DNA-interacting Proteins as Anticancer Drug Targets; High-field NMR spectroscopy |
| Donna Zhang Pharmacology and Toxicology |
The Nrf2/Keap1 signaling pathway that is activated by oxidative stress and chemopreventive compounds; Regulation of gene expression by the ubiquitination and proteasomal degradation pathway |
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