Tatiana SHOKHIREVA

Ph.D. in Chemistry

Research Interests and Skills

Over ten years I have been working at the University of Arizona as a research scientist. I was involved in several projects providing NMR study of heme proteins -Nitrophorins. The goal of this research was to find out, how mutations effects heme center structure and dynamic and how the active center structure effects protein physiological functions.

I also studded by NMR model systems of heme proteins- porphyrins and chlorines.

In my research I used the following 2D NMR techniques: WEFT NOESY, DQF COSY, WEFT ROESY, HMQC, HSQC.

I have extensive experience working with Bruker DRX500 and DRX600 and also Varian 300 and Inova 600 spectrometers.

In my research I also used data obtained by EPR spectroscopy and Electrochemistry.

My previous experience includes research in heterogeneous catalysis, oxidations reactions, oxide catalysts preparation and investigations by instrumental methods.
 

Summary

• NMR and EPR study of Fe(III)porphyrins - the model systems of Hemeproteins.
• NMR and EPR study of Heme proteins:
• Heme center structure and dynamic behavior (including axial ligand rotation, macrocycle inversion and ligand exchange).
• Effect of the heme center structure on protein physiological functions (binding ability, redox potentials etc.).
• Heterogeneous catalysis: oxidation reactions, oxide catalysts preparation (including Heteropolycompounds).

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